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KMID : 0861020130280020025
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Korea Journal of Herbology
2013 Volume.28 No. 2 p.25 ~ p.31
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The Effect of Femented Platycodon grandiflorum on the Memory Impairment of Mice
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김태연:Kim Tae-Yeon
신용욱:Shin Yong-Wook
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Abstract
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Objectives : The purpose of this study was to characterize the effect of the Ethanolic extracts of Platycodon grandiflorum and its permented production the learning and memory impairments induced by scopolamine.
Methods : The cognition-enhancing effect of Platycodon grandiflorum and its permented production were investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.).
Results : The results showed that the Permented Platycodon grandiflorum extract-treated group (100 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Water maze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect.
Conclusions : These results suggest that 80% Ethanol extract of fermented P.grandiflorum showed significant anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent of the learning models.
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KEYWORD
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Platycodon grandiflorum, Permentation, Memory enhancing, scopolamine
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